Abstract
An estrogen receptor and progesterone receptor positive endometrial carcinoma (EnCa101) will grow in response to either estradiol or tamoxifen when transplanted into athymic mice. We have tested several antiestrogens with different properties to determine their ability to support endometrial tumor growth. Trioxifene, enclomiphene and nafoxidine are all as active as tamoxifen whereas the antiestrogen keoxifene, that has reduced estrogen-like properties, will partially inhibit tamoxifen-stimulated growth. Furthermore, the pure antiestrogen ICI 164,384 will block tamoxifen-stimulated growth without having any effect itself on tumor growth rate. Overall, the ability of antiestrogens to stimulate the growth of human endometrial carcinoma EnCa101 appears to be related to their intrinsic estrogenic activity.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Cell Transformation, Neoplastic / drug effects*
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Cell Transformation, Neoplastic / pathology
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Clomiphene / analogs & derivatives
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Clomiphene / pharmacology
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Enclomiphene
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Endometrium / drug effects
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Endometrium / pathology
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Endometrium / ultrastructure
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Estradiol / analogs & derivatives
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Estradiol / pharmacology
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Estrogen Antagonists / pharmacology
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Female
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Humans
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Mice
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Mice, Inbred BALB C
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Nafoxidine / pharmacology
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Neoplasm Transplantation
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Piperidines / pharmacology
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Polyunsaturated Alkamides
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Pyrrolidines / pharmacology
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Raloxifene Hydrochloride
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Receptors, Estrogen / drug effects
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Receptors, Estrogen / metabolism
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Receptors, Progesterone / drug effects
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Receptors, Progesterone / metabolism
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Tamoxifen / pharmacology*
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Uterine Neoplasms / metabolism
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Uterine Neoplasms / pathology*
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Uterine Neoplasms / ultrastructure
Substances
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Antineoplastic Agents
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Estrogen Antagonists
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Piperidines
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Polyunsaturated Alkamides
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Pyrrolidines
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Receptors, Estrogen
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Receptors, Progesterone
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Tamoxifen
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Clomiphene
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Raloxifene Hydrochloride
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Nafoxidine
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Estradiol
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ICI 164384
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trioxifene
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Enclomiphene