Disturbance of cerebral neuronal migration following congenital parvovirus B19 infection

Fetal Diagn Ther. 2008;24(4):491-4. doi: 10.1159/000180119. Epub 2008 Dec 5.

Abstract

Objective: We describe the clinical course of an infant who presented with severe fetal anemia and fetal hydrops following congenital parvovirus B19 infection before 16 gestational weeks. The fetus was treated by cordocentesis and intrauterine transfusion at 18 weeks.

Results: The infant demonstrated mild unilateral ventriculomegaly on antenatal magnetic resonance imaging, and polymicrogyria and heterotopia on postnatal magnetic resonance imaging.

Conclusion: This adds to the evidence in recent literature of central nervous system damage associated with congenital parvovirus B19 infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Transfusion, Intrauterine
  • Brain / abnormalities*
  • Brain / virology
  • Brain Diseases / congenital
  • Brain Diseases / pathology
  • Brain Diseases / virology*
  • Cell Movement
  • Choristoma / congenital
  • Choristoma / pathology
  • Choristoma / virology*
  • Encephalitis, Viral / complications*
  • Encephalitis, Viral / congenital
  • Encephalitis, Viral / pathology
  • Female
  • Humans
  • Hydrops Fetalis / therapy
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Parvoviridae Infections / complications*
  • Parvoviridae Infections / congenital
  • Parvoviridae Infections / pathology
  • Parvovirus B19, Human*
  • Pregnancy
  • Ultrasonography, Prenatal