Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed theories of evolution

Arch Pathol Lab Med. 2008 Dec;132(12):1940-2. doi: 10.5858/132.12.1940.

Abstract

We report a case of an axillary lymph node containing benign glandular lesions, intraductal papilloma with florid and atypical duct hyperplasia, and ductal carcinoma in situ. We propose 2 theories for the development of the intraductal papilloma: from adjacent benign glandular inclusions, or from displaced epithelial cells from a previous intraductal papilloma in the ipsilateral breast. This case identifies yet another etiology for false-positive sentinel lymph nodes morphologically and by immunohistochemistry.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Axilla / pathology
  • Biopsy
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / etiology*
  • Breast Neoplasms / pathology
  • Carcinoma, Intraductal, Noninfiltrating / diagnosis
  • Carcinoma, Intraductal, Noninfiltrating / etiology*
  • Carcinoma, Intraductal, Noninfiltrating / pathology
  • Epithelial Cells / pathology
  • Female
  • Humans
  • Lymph Nodes / pathology
  • Middle Aged
  • Papilloma, Intraductal / diagnosis
  • Papilloma, Intraductal / etiology*
  • Papilloma, Intraductal / pathology