Abstract
An interaction between Drosophila HP1a and H3K36 histone demethylase dKDM4A reported in this issue of Molecular Cell (Lin et al., 2008) offers an explanation for association of HP1a with active genes, reinforcing the notion of dynamic interplay among epigenetic marks on histone tails during transcription.
MeSH terms
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Animals
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Chromobox Protein Homolog 5
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Chromosomal Proteins, Non-Histone / chemistry
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Chromosomal Proteins, Non-Histone / metabolism*
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Drosophila melanogaster / cytology
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Drosophila melanogaster / enzymology*
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Histones / metabolism
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Lysine / metabolism
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Methylation
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Models, Biological
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Oxidoreductases, N-Demethylating / chemistry
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Oxidoreductases, N-Demethylating / metabolism*
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Protein Structure, Tertiary
Substances
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Chromosomal Proteins, Non-Histone
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Histones
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Chromobox Protein Homolog 5
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Oxidoreductases, N-Demethylating
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Lysine