The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci

M Parmentier; E Passage; G Vassart; M G Mattei

doi:10.1159/000133111

The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci

Cytogenet Cell Genet. 1991;57(1):41-3. doi: 10.1159/000133111.

Authors

M Parmentier¹, E Passage, G Vassart, M G Mattei

Affiliation

¹ IRIBHN, Université libre de Bruxelles, Belgium.

PMID: 1906795
DOI: 10.1159/000133111

Abstract

The genes encoding calbindin D28k (CALB1) and calretinin (CALB2), two closely related calcium-binding proteins, were mapped by in situ hybridization to the 8q21.3----q22.1 and 16q22----q23 regions of the human genome, respectively. These localizations match the chromosomal regions where the carbonic anhydrase isozyme gene cluster (CA1, CA2, CA3) and the related gene CA7 have been described, respectively. This suggests a common duplication o the calbindin/calretinin and the carbonic anhydrase ancestral genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calbindin 1
Calbindin 2
Calbindins
Carbonic Anhydrases / genetics*
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 16*
Chromosomes, Human, Pair 8*
Humans
Hybrid Cells
Isoenzymes / genetics*
Karyotyping
Metaphase
Nucleic Acid Hybridization
S100 Calcium Binding Protein G / genetics*

Substances

CALB1 protein, human
CALB2 protein, human
Calbindin 1
Calbindin 2
Calbindins
Isoenzymes
S100 Calcium Binding Protein G
Carbonic Anhydrases