Abstract
Recent articles have described an increasing number of infections due to Panton-Valentine leukocidin PVL-positive community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) worldwide. We report a case of necrotizing pneumonia successfully treated with levofloxacin in Italy, sustained by a PVL-positive CA-MRSA, belonging to ST88 and carrying a staphylococcal chromosomal cassette mec type V. Further molecular characterization of isolates revealed that they were PVL positive, belonged to the agr IV allele, possessed a capsular type 8, and had an almost complete pathotype composed of leukocidins and numerous adhesins. In addition, the strains were strong biofilm producers.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Bacterial Proteins / genetics
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Bacterial Toxins / genetics
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Community-Acquired Infections / diagnosis
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Community-Acquired Infections / drug therapy
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Community-Acquired Infections / microbiology*
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DNA Primers / genetics
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Exotoxins / genetics
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Humans
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Italy
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Leukocidins / genetics
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Levofloxacin
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Male
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Methicillin Resistance / genetics*
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Methicillin-Resistant Staphylococcus aureus / genetics*
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Methicillin-Resistant Staphylococcus aureus / isolation & purification
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Methicillin-Resistant Staphylococcus aureus / pathogenicity
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Microbial Sensitivity Tests
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Ofloxacin / therapeutic use
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Pneumonia, Staphylococcal / diagnosis
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Pneumonia, Staphylococcal / drug therapy
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Pneumonia, Staphylococcal / microbiology*
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Polymerase Chain Reaction
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Serotyping
Substances
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Bacterial Proteins
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Bacterial Toxins
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DNA Primers
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Exotoxins
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Leukocidins
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Panton-Valentine leukocidin
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Levofloxacin
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Ofloxacin