We describe a 32-year-old man who presented in a febrile, unconscious state with unusual staphylococcal endocarditis. We diagnosed the patient's illness by using transthoracic echocardiography (TTE), which revealed a giant vegetation on the left ventricular lateral wall. The patient had history of aortic valve replacement and coarctoplasty. Conservative treatment using repeated TTEs resulted in successful management of endocarditis and embolic brain abscess. After discharge, the patient underwent aortic reconstruction for the aneurysmatic dilatation of ascending aorta. This report confirms that chronic endocardial trauma may provide a fertile nidus for the development of bacterial vegetation. The clinical, echocardiographic, and laboratory findings contributed to therapeutic decision-making in the management of this case.