Abstract
Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good activity against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Isoquinolines / chemistry
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Isoquinolines / pharmacology
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Staphylococcus epidermidis / drug effects
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Streptomyces / drug effects*
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Streptomyces / genetics
Substances
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Anti-Bacterial Agents
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Isoquinolines
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jadomycin B