Abstract
The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediated gene mobilization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Base Sequence
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Conjugation, Genetic
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Drug Resistance, Bacterial / genetics*
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Enterobacter cloacae / enzymology
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Enterobacter cloacae / genetics
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Enterobacter cloacae / isolation & purification
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Enterobacteriaceae Infections
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Genes, Bacterial*
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Humans
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Molecular Sequence Data
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Open Reading Frames
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Plasmids*
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Quinolones / pharmacology*
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Sequence Analysis, DNA
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beta-Lactamases / biosynthesis
Substances
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Anti-Bacterial Agents
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Quinolones
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beta-Lactamases