The relations between antisocial behavior and depressive symptoms were examined both longitudinally and concurrently in a sample of Italian early-adolescents. Structural equation modelling was applied to 10-month longitudinal data from a sample of 107 youths (54 girls; mean age at baseline = M = 12.5). Early adolescents completed a questionnaire in which they reported antisocial behaviors and depressive symptoms. Results show temporal stability for both constructs. Moreover, results show a significant longitudinal relation between depression at t1 and antisocial behavior at t2. This relation dropped to not significant when controlling for concurrent relations between these two measures of psychosocial adjustment at t2. A multigroup comparison suggests that these findings are similar across gender. Implications of the results for theory and intervention are discussed.