Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker

Jacques Y Roberge; Lalgudi S Harikrishnan; Muthoni G Kamau; Zheming Ruan; Katy Van Kirk; Yalei Liu; Christopher B Cooper; Michael A Poss; John K Dickson Jr; Ashvinikumar V Gavai; Sam T Chao; Leslie W Leith; Mark S Bednarz; Arvind Mathur; Ramesh Kakarla; Dora M Schnur; Roy Vaz; R Michael Lawrence

doi:10.1021/cc800051u

Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker

J Comb Chem. 2009 Jan-Feb;11(1):72-82. doi: 10.1021/cc800051u.

Authors

Jacques Y Roberge¹, Lalgudi S Harikrishnan, Muthoni G Kamau, Zheming Ruan, Katy Van Kirk, Yalei Liu, Christopher B Cooper, Michael A Poss, John K Dickson Jr, Ashvinikumar V Gavai, Sam T Chao, Leslie W Leith, Mark S Bednarz, Arvind Mathur, Ramesh Kakarla, Dora M Schnur, Roy Vaz, R Michael Lawrence

Affiliation

¹ Bristol-Myers Squibb Company, R&D, Princeton, New Jersey 08543-4000, USA.

PMID: 19086798
DOI: 10.1021/cc800051u

Abstract

A G-Protein-coupled receptor-targeted library of aryloxypropanolamines and aryloxybutanolamines was efficiently executed using a novel, polymer-supported acyclic acetal linker, producing compounds in good yields and purities.

MeSH terms

Amines / chemical synthesis*
Amines / pharmacology
Combinatorial Chemistry Techniques
Cross-Linking Reagents
Drug Design*
Humans
Polymers
Propanolamines
Receptors, G-Protein-Coupled / antagonists & inhibitors*
Small Molecule Libraries / chemical synthesis*
Small Molecule Libraries / pharmacology

Substances

Amines
Cross-Linking Reagents
Polymers
Propanolamines
Receptors, G-Protein-Coupled
Small Molecule Libraries