Abstract
Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4(+) T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology
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Cytokines / immunology
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Cytotoxicity, Immunologic*
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Gene Expression Profiling
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Humans
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Killer Cells, Natural / immunology
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Macaca mulatta
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Mouth Mucosa / immunology*
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Mouth Mucosa / virology*
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Simian Immunodeficiency Virus / immunology*
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Simian Immunodeficiency Virus / pathogenicity*