Abstract
The aim of this study was to evaluate the biological correlation and prognostic impact of Gata-1, Gata-2, EKLF, and c-MPL transcript level in a group of 41 acute myeloid leukemia (AML) patients. Gata-1 overexpression was related to advanced age and a low percentage of bone marrow blasts and was associated with the expression of CD34 antigen and lymphoid T markers. The negative impact of Gata-1 expression on the probability of achieving complete remission has been confirmed. Gata-2 overexpression was associated with a low percentage of blasts in BM and males. Expression of c-MPL was associated with CD34+ AML and M2 FAB AML subtype. A higher expression of EKLF was found in secondary AML versus primary AML. Nevertheless, patients expressing EKLF had a longer overall survival and event free survival than those patients that did not express EKLF. Our study has identified expression of EKLF as a factor with a favorable impact on prognosis in AML.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Bone Marrow / pathology
-
Chromosome Aberrations
-
Disease-Free Survival
-
Erythropoiesis / genetics
-
GATA1 Transcription Factor / analysis
-
GATA1 Transcription Factor / physiology*
-
GATA2 Transcription Factor / analysis
-
GATA2 Transcription Factor / physiology*
-
Gene Expression Regulation, Neoplastic*
-
Humans
-
Kruppel-Like Transcription Factors / analysis
-
Kruppel-Like Transcription Factors / physiology*
-
Leukemia, Myeloid, Acute / genetics*
-
Leukemia, Myeloid, Acute / metabolism
-
Leukemia, Myeloid, Acute / mortality
-
Leukemia, Myeloid, Acute / pathology
-
Middle Aged
-
Neoplasm Proteins / analysis
-
Neoplasm Proteins / physiology*
-
Neoplasms, Second Primary / genetics
-
Neoplasms, Second Primary / metabolism
-
Neoplasms, Second Primary / mortality
-
Neoplasms, Second Primary / pathology
-
Prognosis
-
Receptors, Thrombopoietin / analysis
-
Receptors, Thrombopoietin / physiology*
-
Survival Analysis
-
Young Adult
Substances
-
GATA1 Transcription Factor
-
GATA1 protein, human
-
GATA2 Transcription Factor
-
GATA2 protein, human
-
Kruppel-Like Transcription Factors
-
Neoplasm Proteins
-
Receptors, Thrombopoietin
-
erythroid Kruppel-like factor
-
MPL protein, human