Xeroderma pigmentosum: neck lymph node metastasis of a squamous cell carcinoma of the skin treated with cetuximab

Jordi Rubió Casadevall; Begoña Graña-Suárez; Xavier Hernandez-Yagüe; Jordi Vayreda Ribera; Oscar Huc Grasa; Joan Brunet Vidal

doi:10.1684/ejd.2008.0574

Xeroderma pigmentosum: neck lymph node metastasis of a squamous cell carcinoma of the skin treated with cetuximab

Eur J Dermatol. 2009 Mar-Apr;19(2):163-5. doi: 10.1684/ejd.2008.0574. Epub 2008 Dec 23.

Authors

Jordi Rubió Casadevall¹, Begoña Graña-Suárez, Xavier Hernandez-Yagüe, Jordi Vayreda Ribera, Oscar Huc Grasa, Joan Brunet Vidal

Affiliation

¹ Department of Medical Oncology, Catalan Institute of Oncology, Hospital Josep Trueta, AV Francia s/n 17007 Girona, Spain. [email protected]

PMID: 19106040
DOI: 10.1684/ejd.2008.0574

Abstract

Xeroderma pigmentosum is a genodermatosis characterized by defects in the DNA nucleotide excision repair pathway, which increases the risk of suffering skin cancers. There is lack of information about the efficacy and toxicity of chemotherapy and radiotherapy in the treatment of these patients. We present the case of a xeroderma pigmentosum patient with a neck node recurrence of a squamous cell skin carcinoma that achieved a good response and survival with cetuximab.

Publication types

Case Reports

MeSH terms

Adult
Antibodies, Monoclonal / therapeutic use
Antibodies, Monoclonal, Humanized
Antineoplastic Agents / therapeutic use
Carcinoma, Squamous Cell / genetics
Carcinoma, Squamous Cell / pathology*
Carcinoma, Squamous Cell / therapy
Cetuximab
Combined Modality Therapy
Fatal Outcome
Humans
Lymphatic Metastasis
Male
Neck
Skin Neoplasms / genetics
Skin Neoplasms / pathology*
Skin Neoplasms / therapy
Xeroderma Pigmentosum / genetics
Xeroderma Pigmentosum / pathology*

Substances

Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Antineoplastic Agents
Cetuximab