Population snapshot of Streptococcus pneumoniae serotype 19A isolates before and after introduction of seven-valent pneumococcal Vaccination for French children

Farah Mahjoub-Messai; Catherine Doit; Jean-Louis Koeck; Typhaine Billard; Bénédicte Evrard; Philippe Bidet; Christine Hubans; Josette Raymond; Corinne Levy; Robert Cohen; Edouard Bingen

doi:10.1128/JCM.01547-08

Population snapshot of Streptococcus pneumoniae serotype 19A isolates before and after introduction of seven-valent pneumococcal Vaccination for French children

J Clin Microbiol. 2009 Mar;47(3):837-40. doi: 10.1128/JCM.01547-08. Epub 2008 Dec 24.

Authors

Farah Mahjoub-Messai¹, Catherine Doit, Jean-Louis Koeck, Typhaine Billard, Bénédicte Evrard, Philippe Bidet, Christine Hubans, Josette Raymond, Corinne Levy, Robert Cohen, Edouard Bingen

Affiliation

¹ Service de Microbiologie, Hôpital Robert-Debré (APHP), 75019 Paris, France.

Abstract

Serotype 19A Streptococcus pneumoniae strains are now more frequent in French children than before the introduction of a seven-valent conjugate vaccine (PCV7). By applying multilocus sequence typing to 144 serotype 19A isolates collected before and after beginning PCV7 vaccination, we detected clonal expansion of the preexisting penicillin-intermediate sequence type 276.

MeSH terms

Anti-Bacterial Agents / pharmacology
Bacterial Typing Techniques
Cluster Analysis
France / epidemiology
Genotype
Heptavalent Pneumococcal Conjugate Vaccine
Humans
Infant
Penicillins / pharmacology
Pneumococcal Infections / epidemiology*
Pneumococcal Infections / microbiology*
Pneumococcal Vaccines / immunology*
Prevalence
Sequence Analysis, DNA
Serotyping
Streptococcus pneumoniae / isolation & purification*

Substances

Anti-Bacterial Agents
Heptavalent Pneumococcal Conjugate Vaccine
Penicillins
Pneumococcal Vaccines