Search for serum biomarkers associated with abdominal aortic aneurysm growth--a pilot study

M Vega de Céniga; M Esteban; J M Quintana; A Barba; L Estallo; N de la Fuente; B Viviens; J L Martin-Ventura

doi:10.1016/j.ejvs.2008.11.014

Search for serum biomarkers associated with abdominal aortic aneurysm growth--a pilot study

Eur J Vasc Endovasc Surg. 2009 Mar;37(3):297-9. doi: 10.1016/j.ejvs.2008.11.014. Epub 2008 Dec 25.

Authors

M Vega de Céniga¹, M Esteban, J M Quintana, A Barba, L Estallo, N de la Fuente, B Viviens, J L Martin-Ventura

Affiliation

¹ Department of Angiology and Vascular Surgery, Hospital de Galdakao-Usansolo, Bizkaia, Spain. [email protected]

PMID: 19111482
DOI: 10.1016/j.ejvs.2008.11.014

Abstract

Introduction: Serological biomarkers could reflect asymptomatic infrarenal aortic aneurysm (AAA) activity and guide patient management.

Report: Serum concentrations of C-reactive protein (CRP), alpha 1-antitrypsin and lipoprotein(a) were measured in blood samples from 35 AAA patients and 35 controls and correlated with the aortic diameter and AAA growth in the previous 12 months. We found a positive correlation between CRP and AAA diameter (r=0.46; p=0.007) and alpha 1-antitrypsin and AAA growth (r=0.55; p=0.004).

Conclusions: Alpha 1-antitrypsin may be a promising biomarker of AAA growth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal / blood*
Aortic Aneurysm, Abdominal / pathology*
Biomarkers / blood
C-Reactive Protein / analysis*
Case-Control Studies
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Lipoprotein(a) / blood*
Male
Middle Aged
Multivariate Analysis
Pilot Projects
alpha 1-Antitrypsin / blood*

Substances

Biomarkers
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipoprotein(a)
alpha 1-Antitrypsin
C-Reactive Protein