Abstract
Among 57 metallo-beta-lactamase (MbetaL)-producing Pseudomonas spp. detected in India during 2006, five bla(VIM) genes were found, including a newly characterized bla(VIM) gene. Pseudomonas aeruginosa strains were clustered in 33 ribotypes with clones found in multiple hospitals. Several types of bla(VIM-2)-carrying integrons were detected. The newly characterized variant VIM-18 showed a 4-amino-acid deletion compared to other VIM variants. In this study, we show that VIM-producing Pseudomonas spp. were highly prevalent in India with a great diversity of bla(VIM) types and MbetaL-carrying integrons.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Base Sequence
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Carbapenems / pharmacology*
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Drug Resistance, Bacterial / genetics*
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Humans
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India / epidemiology
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Prevalence
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Pseudomonas aeruginosa* / drug effects
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Pseudomonas aeruginosa* / enzymology
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Pseudomonas aeruginosa* / genetics
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Pseudomonas aeruginosa* / isolation & purification
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Ribotyping
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beta-Lactamases / classification*
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-lactamase bla(vim-2)
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beta-Lactamases
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beta-lactamase VIM-11, Pseudomonas aeruginosa
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beta-lactamase VIM-18, Pseudomonas aeruginosa
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beta-lactamase VIM-5, Pseudomonas aeruginosa
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beta-lactmase VIM-6, Pseudomonas aeruginosa