Primary lymphoma of the head and neck: two case reports and review of the literature

Ismail Essadi; Nabil Ismaili; Elmehdi Tazi; Sanaa Elmajjaoui; Ammar Saidi; Mohammed Ichou; Hassan Errihani

doi:10.1186/1757-1626-1-426

Primary lymphoma of the head and neck: two case reports and review of the literature

Cases J. 2008 Dec 30;1(1):426. doi: 10.1186/1757-1626-1-426.

Authors

Ismail Essadi^#¹, Nabil Ismaili^#², Elmehdi Tazi², Sanaa Elmajjaoui³, Ammar Saidi⁴, Mohammed Ichou¹, Hassan Errihani²

Affiliations

¹ Department of Medical Oncology, Mohamed V Military Hospital, Rabat, Morocco.
² Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
³ Department of Radiotherapy, National Institute of Oncology, Rabat, Morocco.
⁴ Center pathology UN, Rabat, Morocco.

^# Contributed equally.

Abstract

Background: The head and neck is the second most common region for the extra-nodal lymphomas after that of gastrointestinal tract. Approximately 2.5% of malignant lymphoma arises in the oral and para-oral region. In this paper we report two cases of early stage head and neck lymphoma which were managed successfully with chemotherapy and a review of the related literature.

Cases presentation: The first case concerns a 48 years male patient having a diffuse large B-Cell lymphoma of the oropharynx at early bulky stage. This patient was managed successfully with 7 of Rituximab 375 mg/m2, Cyclophosphamide 750 mg/m2 d1, Doxorubicine 50 mg/m2 d1, Vincristine 1.4 mg/m2 d1, and prednisone 50 mg/m2 d1-5 (RCHOP) regimen. The second case concerns a 50 years female patient having the nasal natural killer (NK)/T-cell lymphoma of the left nasal pit at early stage. This case was managed successfully with 6 of Cyclophosphamide 750 mg/m2 d1, Doxorubicine 50 mg/m2 d1, Vincristine 1.4 mg/m2 d1, and prednisone 50 mg/m2 d1-5 (CHOP) regimen.

Conclusion: These two cases highlight the important role of CHOP based chemotherapy for achieving successful treatment cure for patients having an early stage head and neck lymphoma.