[Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy]

Med Mal Infect. 2009 Dec;39(12):906-8. doi: 10.1016/j.medmal.2008.11.007. Epub 2008 Dec 31.
[Article in French]

Abstract

Introduction: Metronidazole is a widely prescribed treatment for amoebic and anaerobic germ infections. Its neurologic toxicity is rare but can be serious.

Case report: We report the case of a 27-year-old male patient, treated with metronidazole for a cerebral abscess. He presented with a cerebellar syndrome and peripheral neuropathy at a cumulative metronidazole dose of 60g. The MRI aspect of the cerebellar lesions in addition to their reversibility after treatment cessation led to the diagnosis of metronidazole induced neurologic toxicity.

Conclusion: The occurrence of neurologic disorders in patients treated with metronidazole must suggest drug toxicity and lead to cessation of treatment.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Brain Abscess / drug therapy*
  • Cerebellar Diseases / chemically induced*
  • Cerebellar Diseases / diagnosis
  • Consciousness Disorders / chemically induced
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Metronidazole / adverse effects*
  • Metronidazole / therapeutic use
  • Peripheral Nervous System Diseases / chemically induced*
  • Sensation Disorders / chemically induced

Substances

  • Metronidazole