Abstract
Albidopyrone, a new alpha-pyrone-containing secondary metabolite, was produced by Streptomyces sp. NTK 227, a strain isolated from Atlantic Ocean sediment and found to be a member of the Streptomyces albidoflavus 16S rRNA gene clade. The structure of the compound was determined by MS and NMR spectroscopy, and found to have a moderate inhibitory activity against protein-tyrosin phosphatase B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / chemistry*
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Acetamides / pharmacology
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Chromatography, High Pressure Liquid
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Fermentation
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Pyrones / chemistry*
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Pyrones / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Streptomyces / chemistry*
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Streptomyces / classification
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Streptomyces / metabolism
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Water Microbiology
Substances
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Acetamides
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Anti-Bacterial Agents
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Pyrones
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albidopyrone