Abstract
The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a universal intracellular Ca2+-release channel. It is activated after cell stimulation and plays a crucial role in the initiation and propagation of the complex spatio-temporal Ca2+ signals that control cellular processes as different as fertilization, cell division, cell migration, differentiation, metabolism, muscle contraction, secretion, neuronal processing, and ultimately cell death. To achieve these various functions, often in a single cell, exquisite control of the Ca2+ release is needed. This review aims to highlight how protein kinases and protein phosphatases can interact with the IP3R or with associated proteins and so provide a large potential for fine tuning the Ca2+-release activity and for creating efficient Ca2+ signals in subcellular microdomains.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Signaling / physiology*
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Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism
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Cyclic AMP-Dependent Protein Kinases / metabolism
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Cyclic GMP-Dependent Protein Kinases / metabolism
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Cyclin-Dependent Kinases / metabolism
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Humans
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Inositol 1,4,5-Trisphosphate / metabolism*
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Inositol 1,4,5-Trisphosphate Receptors / chemistry
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Inositol 1,4,5-Trisphosphate Receptors / genetics
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Inositol 1,4,5-Trisphosphate Receptors / metabolism*
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Lectins, C-Type / genetics
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Lectins, C-Type / metabolism
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Phosphorylation
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Protein Kinase C / metabolism
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Protein-Tyrosine Kinases / metabolism
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Proto-Oncogene Proteins c-akt / metabolism
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Proto-Oncogene Proteins c-bcl-2 / chemistry
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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rho-Associated Kinases / metabolism
Substances
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CLECL1 protein, human
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Inositol 1,4,5-Trisphosphate Receptors
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Lectins, C-Type
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Membrane Proteins
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Proto-Oncogene Proteins c-bcl-2
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Inositol 1,4,5-Trisphosphate
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-akt
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rho-Associated Kinases
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Cyclic AMP-Dependent Protein Kinases
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Cyclic GMP-Dependent Protein Kinases
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Protein Kinase C
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Cyclin-Dependent Kinases
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Calcium