Abstract
The synthesis of 2',2'-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD1 / immunology*
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Cytokines / blood
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Cytokines / immunology
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Galactosylceramides / chemical synthesis*
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Galactosylceramides / pharmacology*
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Lymphocyte Activation / drug effects*
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Mice
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Mice, Inbred C57BL
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Natural Killer T-Cells
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Receptors, Natural Killer Cell / immunology
Substances
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2',2'-difluoro KRN7000
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Antigens, CD1
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Cytokines
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Galactosylceramides
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Receptors, Natural Killer Cell