Abstract
We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Candida albicans / genetics
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Candida albicans / immunology*
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Candidiasis / immunology
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Candidiasis / prevention & control*
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Fungal Vaccines / genetics
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Fungal Vaccines / immunology*
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Mice
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Neuregulin-1 / genetics
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Neuregulin-1 / immunology*
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Survival Analysis
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T-Lymphocytes / immunology
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Vaccines, Attenuated / genetics
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Vaccines, Attenuated / immunology
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Vaccines, Synthetic / genetics
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Vaccines, Synthetic / immunology
Substances
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Fungal Vaccines
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Neuregulin-1
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Vaccines, Attenuated
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Vaccines, Synthetic