In situ hybridization of two markers closely flanking the spinal muscular atrophy gene to 5q12----q13.3

M G Mattei; J Melki; M F Bachelot; S Abdelhak; P Burlet; J Frézal; A Munnich

doi:10.1159/000133125

In situ hybridization of two markers closely flanking the spinal muscular atrophy gene to 5q12----q13.3

Cytogenet Cell Genet. 1991;57(2-3):112-3. doi: 10.1159/000133125.

Authors

M G Mattei¹, J Melki, M F Bachelot, S Abdelhak, P Burlet, J Frézal, A Munnich

Affiliation

¹ Unité de Recherches de Physiopathologie Chromosomique, INSERM U-242, Hôpital de La Timone, Marseille, France.

PMID: 1914518
DOI: 10.1159/000133125

Abstract

In order to refine the physical location of the p105-153Ra and M4 probes which closely flank the spinal muscular atrophy gene (SMA) on human chromosome 5q, in situ hybridization has been carried out on prometaphase chromosomes. Our results demonstrate that the disease gene is located between the 5q12----q13.1 and 5q13.3 bands. The present study will hopefully contribute to microdissection of the chromosomal region of the SMA gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 12*
Humans
Karyotyping
Muscular Atrophy, Spinal / genetics*
Nucleic Acid Hybridization