Correlation of survival motor neuron expression in leukocytes and spinal cord in spinal muscular atrophy

Li-Kai Tsai; Chih-Chao Yang; Chen-Hung Ting; Yi-Ning Su; Wuh-Liang Hwu; Hung Li

doi:10.1016/j.jpeds.2008.08.050

Correlation of survival motor neuron expression in leukocytes and spinal cord in spinal muscular atrophy

J Pediatr. 2009 Feb;154(2):303-5. doi: 10.1016/j.jpeds.2008.08.050.

Authors

Li-Kai Tsai¹, Chih-Chao Yang, Chen-Hung Ting, Yi-Ning Su, Wuh-Liang Hwu, Hung Li

Affiliation

¹ Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

PMID: 19150680
DOI: 10.1016/j.jpeds.2008.08.050

Abstract

Survival motor neuron (SMN) messenger RNA and protein levels in spinal muscular atrophy (SMA) model mice and in patients with SMA were measured. There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a moderate correlation between leukocyte SMN expression and age of disease onset in patients with SMA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age of Onset
Animals
Female
Humans
Leukocytes / metabolism*
Male
Mice
Muscular Atrophy, Spinal / classification
Muscular Atrophy, Spinal / metabolism*
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
SMN Complex Proteins / metabolism*
Spinal Cord / metabolism*

Substances

RNA, Messenger
SMN Complex Proteins