Resolution of sequencing ambiguities: a universal FokI adapter permits Maxam-Gilbert re-sequencing of single-stranded phagemid DNA

Gene. 1991 Jul 31;104(1):71-4. doi: 10.1016/0378-1119(91)90466-o.

Abstract

We propose a method to resolve ambiguities encountered when single-stranded (ss) phagemid DNA templates are sequenced by the dideoxy method. A single oligodeoxyribonucleotide (oligo) is synthesized with the following features: (i) the 20 nucleotides (nt) at the 5'-end form a double-stranded hairpin containing a FokI restriction site, exactly as previously described by Podhajska and Szybalski [Gene 40 (1985) 175-182]; (ii) the 23 nt at the 3'-end hybridize to the (+)strand of ss phagemid DNA in the region complementary to the M13 universal sequencing primer. In a simple one-tube set of reactions, ss phagemid DNA is annealed to this oligo, cleaved by FokI at a unique site outside the vector multiple cloning site and then labelled at this unique site by Klenow polymerase and [alpha-32P]dCTP. These reactions provide a convenient route by which Maxam-Gilbert chemical degradation sequencing methods can be used to resolve ambiguities encountered in the dideoxy-sequencing of a unidirectional deletion series already prepared in popular phagemid vectors. A single oligo allows labelling of all members of a deletion series. A second universal oligo allows the same set of reactions to be applied to inserts cloned into (-)strand phagemids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Caenorhabditis / genetics*
  • Chromosome Deletion
  • DNA, Single-Stranded / genetics*
  • DNA, Viral / genetics*
  • Deoxyribonucleases, Type II Site-Specific
  • Genetic Techniques
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides / chemical synthesis
  • Restriction Mapping
  • Templates, Genetic
  • Viruses / genetics

Substances

  • DNA, Single-Stranded
  • DNA, Viral
  • Oligodeoxyribonucleotides
  • endodeoxyribonuclease FokI
  • Deoxyribonucleases, Type II Site-Specific