A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype

Neurogenetics. 2009 Jul;10(3):271-3. doi: 10.1007/s10048-009-0173-5. Epub 2009 Jan 27.

Abstract

The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is recognized as the most common cause of familial autosomal dominant and also sporadic forms of Parkinson disease (PD). A common founder has been described for most Europeans and all North Africans and Jews; besides, two distinct G2019S LRRK2 haplotypes were found in a small proportion of European families and in Japanese PD patients. This study revealed a Turkish patient heterozygous for the G2019S mutation sharing the Japanese haplotype. To the best of our knowledge, it is the first time that the G2019S-associated Japanese haplotype has been reported in a different population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Asian People / genetics*
  • DNA Mutational Analysis
  • Female
  • Genetics, Population
  • Haplotypes
  • Heterozygote*
  • Humans
  • Japan
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Middle Aged
  • Molecular Sequence Data
  • Parkinson Disease / genetics
  • Point Mutation*
  • Protein Serine-Threonine Kinases / genetics*
  • Turkey

Substances

  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein Serine-Threonine Kinases