Abstract
A fluorous-tagged "safety catch" linker is described for the synthesis of heterocycles with use of ring-closing metathesis. The linker facilitates the purification of metathesis substrates, the removal of the catalyst, the functionalization of the products, and the release of only metathesis products. The synthesis of a range of heterocycles is described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Combinatorial Chemistry Techniques
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Cross-Linking Reagents / chemistry
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Cyclization
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Hydrocarbons, Fluorinated / chemistry*
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Molecular Structure
Substances
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Cross-Linking Reagents
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Heterocyclic Compounds
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Hydrocarbons, Fluorinated