Synthesis of (E)- and (Z)-alpha,beta-Difluorourocanic Acid

J Fluor Chem. 2008 Feb;129(2):112-118. doi: 10.1016/j.jfluchem.2007.09.006.

Abstract

Horner-Emmons fluoroolefination of an aryl aldehyde followed by introduction of a second fluorine via "FBr" addition provides an original approach to the preparation of 1-alkyl-2-aryl-1,2-difluoroethenes. The utility of this procedure is demonstrated by the preparation of (E and Z)-alpha,beta-difluorourocanic acid.