Antagonists of the P2X(7) receptor. From lead identification to drug development

J Med Chem. 2009 May 28;52(10):3123-41. doi: 10.1021/jm801528x.
No abstract available

Publication types

  • Review

MeSH terms

  • Amides / chemistry
  • Amides / pharmacology
  • Amides / therapeutic use
  • Amidines / chemistry
  • Amidines / pharmacology
  • Amidines / therapeutic use
  • Animals
  • Arthritis, Rheumatoid / drug therapy
  • Azoles / chemistry
  • Azoles / pharmacology
  • Azoles / therapeutic use
  • Drug Discovery*
  • Humans
  • Purinergic P2 Receptor Antagonists*
  • Receptors, Purinergic P2X7
  • Structure-Activity Relationship

Substances

  • Amides
  • Amidines
  • Azoles
  • P2RX7 protein, human
  • Purinergic P2 Receptor Antagonists
  • Receptors, Purinergic P2X7