Abstract
The efficient synthesis of a range of stable SAM mimetics, and their ability to promote the binding of the E. coli methionine repressor (MetJ) to its operator DNA, is described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / metabolism*
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DNA / metabolism*
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Escherichia coli Proteins
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Ligands
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Protein Binding / drug effects
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Repressor Proteins / metabolism*
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S-Adenosylmethionine / analogs & derivatives*
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S-Adenosylmethionine / chemical synthesis
Substances
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Bacterial Proteins
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Escherichia coli Proteins
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Ligands
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Repressor Proteins
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methionine repressor protein, Bacteria
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S-Adenosylmethionine
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DNA