Abstract
A racemic mixture of a new bicyclononane aldehyde, (1 RS,5 SR,6 RS)-5-hydroxybicyclo[4.3.0]non-2-ene-2-carbaldehyde (1) was isolated from the fruits of Amomum tsao-ko, together with 12 known compounds (2-13). The structure of 1 was determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR data. The antiproliferative activity of compounds 1-13 was assessed in the murine neuroblastoma cell line N2a.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Aldehydes / isolation & purification*
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Aldehydes / pharmacology
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Amomum / chemistry*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Bridged Bicyclo Compounds / chemistry
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Bridged Bicyclo Compounds / isolation & purification*
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Bridged Bicyclo Compounds / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Fruit
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Mice
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Molecular Structure
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Neuroblastoma
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
Substances
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(1RS,5SR,6RS)-5-hydroxybicyclo(4.3.0)non-2-ene-2-carbaldehyde
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Aldehydes
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Antineoplastic Agents, Phytogenic
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Bridged Bicyclo Compounds
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Plant Extracts