In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots

Raghavendra Kikkeri; Bernd Lepenies; Alexander Adibekian; Paola Laurino; Peter H Seeberger

doi:10.1021/ja807711w

In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots

J Am Chem Soc. 2009 Feb 18;131(6):2110-2. doi: 10.1021/ja807711w.

Authors

Raghavendra Kikkeri¹, Bernd Lepenies, Alexander Adibekian, Paola Laurino, Peter H Seeberger

Affiliation

¹ Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland.

PMID: 19199612
DOI: 10.1021/ja807711w

Abstract

PEGylated quantum dots (QDs) capped with d-mannose, d-galactose, and d-galactosamine have been synthesized. The stable, high quantum yield fluorescence of QDs was exploited to study specific carbohydrate-protein interactions in vitro and in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Asialoglycoprotein Receptor / metabolism
Cell Line, Tumor
Flow Cytometry
Galactosamine / chemistry*
Galactose / chemistry*
Humans
Liver / drug effects
Liver / metabolism*
Mannose / chemistry*
Mice
Polyethylene Glycols / chemical synthesis
Polyethylene Glycols / chemistry*
Quantum Dots*

Substances

Asialoglycoprotein Receptor
Polyethylene Glycols
Galactosamine
Mannose
Galactose