Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia

Pediatr Hematol Oncol. 2009 Jan;26(1):48-56. doi: 10.1080/08880010802625530.

Abstract

PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Biomarkers, Tumor
  • Bone Marrow / pathology
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Gene Expression Regulation, Leukemic
  • Humans
  • Immunohistochemistry
  • Infant
  • Male
  • PTEN Phosphohydrolase / analysis*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6 / analysis*
  • Tissue Array Analysis

Substances

  • Biomarkers, Tumor
  • PTPN6 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • PTEN Phosphohydrolase
  • PTEN protein, human