[Hemolytic-uremic syndrome: what is the mechanism?]

Rev Prat. 2008 Dec 15;58(19):2093-6.
[Article in French]

Abstract

Many data suggest that improper regulation of the alternative complement pathway is involved in the pathophysiology of atypical hemolytic-uremic syndrome. Until a few years ago, research exclusively focused on protein assays, which did not help to identify precise genetic factors predisposing to atypical hemolytic-uremic syndrome. In this context, the introduction of gene study considerably accelerated advances.

MeSH terms

  • Genetic Predisposition to Disease
  • Hemolytic-Uremic Syndrome / genetics*
  • Hemolytic-Uremic Syndrome / physiopathology
  • Humans
  • Membrane Cofactor Protein / genetics

Substances

  • CD46 protein, human
  • Membrane Cofactor Protein