Targeting exofacial protein thiols with Gd(III) complexes. An efficient procedure for MRI cell labelling

Giuseppe Digilio; Valeria Catanzaro; Franco Fedeli; Eliana Gianolio; Valeria Menchise; Roberta Napolitano; Concetta Gringeri; Silvio Aime

doi:10.1039/b820593k

Targeting exofacial protein thiols with Gd(III) complexes. An efficient procedure for MRI cell labelling

Chem Commun (Camb). 2009 Feb 28:(8):893-5. doi: 10.1039/b820593k. Epub 2009 Jan 26.

Authors

Giuseppe Digilio¹, Valeria Catanzaro, Franco Fedeli, Eliana Gianolio, Valeria Menchise, Roberta Napolitano, Concetta Gringeri, Silvio Aime

Affiliation

¹ Department of Environmental and Life Sciences, University of Eastern Piedmont "A. Avogadro", Via Bellni 25G, 15100 Alessandria, Italy. [email protected]

PMID: 19214307
DOI: 10.1039/b820593k

Abstract

Cells display on the outer surface of the plasma membrane a large number of protein thiols that can be reversibly labelled with suitably designed Gd(III)-based contrast agents for cell tracking by MRI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Membrane / metabolism*
Cellular Structures / chemistry
Contrast Media / chemistry*
Contrast Media / metabolism
Gadolinium / chemistry*
Humans
K562 Cells
Macromolecular Substances*
Magnetic Resonance Imaging / methods
Molecular Structure
Proteins*
Staining and Labeling / methods*
Sulfhydryl Compounds / chemistry*

Substances

Contrast Media
Macromolecular Substances
Proteins
Sulfhydryl Compounds
Gadolinium