Abstract
Three new saponins, bacopasides IX-XI (1- 3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.
Copyright Georg Thieme Verlag KG Stuttgart. New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacopa / chemistry*
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Disease Models, Animal
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Male
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Memory / drug effects
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Memory Disorders / chemically induced
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Memory Disorders / drug therapy*
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Mice
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Mice, Inbred ICR
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Nootropic Agents / isolation & purification
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Nootropic Agents / pharmacology
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Nootropic Agents / therapeutic use*
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Phytotherapy*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Scopolamine
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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Nootropic Agents
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Plant Extracts
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Triterpenes
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bacopaside IX
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bacopaside XI
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Scopolamine
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bacopaside X