Abstract
This work demonstrates that Vibrio vulnificus biotype 2, serovar E, an eel pathogen able to infect humans, can become resistant to quinolone by specific mutations in gyrA (substitution of isoleucine for serine at position 83) and to some fluoroquinolones by additional mutations in parC (substitution of lysine for serine at position 85). Thus, to avoid the selection of resistant strains that are potentially pathogenic for humans, antibiotics other than quinolones must be used to treat vibriosis on farms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial*
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Eels / microbiology
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Molecular Sequence Data
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Mutation, Missense
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Quinolones / pharmacology*
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Sequence Analysis, DNA
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Vibrio vulnificus / drug effects*
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Vibrio vulnificus / isolation & purification
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA, Bacterial
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Quinolones
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DNA Topoisomerase IV
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DNA Gyrase
Associated data
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GENBANK/FJ379836
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GENBANK/FJ379837
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GENBANK/FJ379838
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GENBANK/FJ379839
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