5-Bromo-8-methoxy-1-methyl-beta-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa

Marisa Till; Michèle R Prinsep

doi:10.1021/np8007655

5-Bromo-8-methoxy-1-methyl-beta-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa

J Nat Prod. 2009 Apr;72(4):796-8. doi: 10.1021/np8007655.

Authors

Marisa Till¹, Michèle R Prinsep

Affiliation

¹ Department of Chemistry, UniVersity of Waikato, Private Bag, Hamilton, New Zealand.

PMID: 19220033
DOI: 10.1021/np8007655

Abstract

A new alkaloid, 5-bromo-8-methoxy-1-methyl-beta-carboline (1), has been isolated from the New Zealand marine bryozoan Pterocella Vesiculosa. Structural elucidation was achieved through NMR spectroscopic and mass spectrometric analysis, and a single-crystal X-ray diffraction analysis of 1 was performed. The biological activity of 1 was assessed against P388 murine leukemia cells and three microorganisms and compared with that of a number of related beta-carboline alkaloids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Bryozoa / chemistry*
Carbolines / chemistry
Carbolines / isolation & purification*
Carbolines / pharmacology
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Leukemia P388
Mice
Molecular Structure
New Zealand
Nuclear Magnetic Resonance, Biomolecular

Substances

5-bromo-8-methoxy-1-methyl-beta-carboline
Alkaloids
Carbolines