Abstract
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens. Members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC are critical components of the inflammasome that link microbial and endogenous 'danger' signals to caspase-1 activation. Several diseases are associated with dysregulated activation of caspase-1 and secretion of IL-1beta. Thus, understanding inflammasome pathways may provide insight into disease pathogenesis that might identify potential targets for therapeutic intervention.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / immunology*
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Adaptor Proteins, Signal Transducing / metabolism
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Apoptosis Regulatory Proteins / immunology*
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Apoptosis Regulatory Proteins / metabolism
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CARD Signaling Adaptor Proteins / immunology*
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CARD Signaling Adaptor Proteins / metabolism
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Calcium-Binding Proteins / immunology*
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Calcium-Binding Proteins / metabolism
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Carrier Proteins / immunology*
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Carrier Proteins / metabolism
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Caspase 1 / immunology*
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Caspase 1 / metabolism
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Humans
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Interleukin-1beta / immunology*
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Interleukin-1beta / metabolism
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLR Proteins
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Protein Interaction Domains and Motifs
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Uric Acid / immunology
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Uric Acid / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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CARD Signaling Adaptor Proteins
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Calcium-Binding Proteins
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Carrier Proteins
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Interleukin-1beta
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLR Proteins
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NLRC4 protein, human
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NLRP1 protein, human
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NLRP3 protein, human
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Uric Acid
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Caspase 1