Wound healing delay after central venous access following DCF/VEGF-trap therapy

Charles Ferté; Christophe Massard; Christian Moldovan; Eric Desruennes; Yohann Loriot; Jean-Charles Soria

doi:10.1007/s10637-009-9227-7

Wound healing delay after central venous access following DCF/VEGF-trap therapy

Invest New Drugs. 2009 Dec;27(6):583-5. doi: 10.1007/s10637-009-9227-7. Epub 2009 Feb 17.

Authors

Charles Ferté¹, Christophe Massard, Christian Moldovan, Eric Desruennes, Yohann Loriot, Jean-Charles Soria

Affiliation

¹ Department of Medicine, Institut Gustave Roussy, Phase I unit (SITEP), 94805, Villejuif, France. [email protected]

PMID: 19221694
DOI: 10.1007/s10637-009-9227-7

Abstract

Hypertension, proteinuria, thromboembolic or bleeding events are well-recognized complications occurring while targeting VEGF pathway. Wound healing dysfunctions have also been described in patients undergoing major surgery. For the first time, we report wound healing delay after central venous access following DCF-VEGF-Trap. VEGF-Trap may affect both angiogenesis and reepithelialization which are necessary to the normal repair process.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Central Venous Catheters / adverse effects*
Cisplatin / adverse effects*
Docetaxel
Fluorouracil / adverse effects*
Humans
Male
Receptors, Vascular Endothelial Growth Factor / adverse effects*
Recombinant Fusion Proteins / adverse effects*
Taxoids / adverse effects*
Wound Healing*

Substances

Recombinant Fusion Proteins
Taxoids
aflibercept
Docetaxel
Receptors, Vascular Endothelial Growth Factor
Cisplatin
Fluorouracil