Abstract
Background:
New organ preservation solutions that contain soluble polyethylene glycol (sPEG) molecules have been associated with reduction of acute rejection episodes.
Methods:
In the present manuscript we tested in vitro whether sPEG molecules were able to mask donor alloantigens and reduce graft immunogenicity.
Results:
Immunomasking effect was only evidenced when PEG molecules were covalently bound to donor cell surface.
Conclusion:
We concluded that sPEG in preservation solution are unlikely to display 'immunocamouflage' property.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Surface / drug effects
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Cell Proliferation / drug effects
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Graft Rejection / prevention & control*
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Humans
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Organ Preservation / methods
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Organ Preservation Solutions / pharmacology
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Organ Preservation Solutions / therapeutic use*
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Organ Transplantation / methods
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Polyethylene Glycols / pharmacology
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Polyethylene Glycols / therapeutic use*
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology
Substances
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Antigens, Surface
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Organ Preservation Solutions
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Polyethylene Glycols