Absence of association of HTLV-I infection with type 1 neurofibromatosis in the United States or Japan

Neurology. 1991 Oct;41(10):1687-9. doi: 10.1212/wnl.41.10.1687.

Abstract

An HTLV-I tax transgenic mouse model develops a syndrome with similarities to type 1 neurofibromatosis (NF-1). To investigate possible associations between this human retrovirus and NF-1, we have analyzed 67 neurofibromas from Japan (where HTLV-I infection is endemic) and compared them with 21 cases from the United States. We were not able to identify virus in tumor tissue in either group. This suggests that HTLV-I infection is not commonly associated with NF-1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • DNA, Viral / analysis
  • HTLV-I Infections / complications*
  • HTLV-I Infections / epidemiology
  • HTLV-I Infections / genetics
  • Humans
  • Japan / epidemiology
  • Molecular Sequence Data
  • Neurofibromatosis 1 / complications*
  • Neurofibromatosis 1 / epidemiology
  • Neurofibromatosis 1 / genetics
  • Polymerase Chain Reaction
  • United States / epidemiology

Substances

  • DNA, Viral