Palettes of vaccines and immunostimulatory monoclonal antibodies for combination

Clin Cancer Res. 2009 Mar 1;15(5):1507-9. doi: 10.1158/1078-0432.CCR-08-2931. Epub 2009 Feb 24.

Abstract

Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / therapeutic use*
  • Cancer Vaccines / immunology
  • Cancer Vaccines / therapeutic use*
  • Drug Combinations
  • Humans
  • Immunity
  • Lymphocyte Activation / immunology
  • Neoplasm Proteins / immunology
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • T-Lymphocytes / immunology

Substances

  • Antibodies, Monoclonal
  • Cancer Vaccines
  • Drug Combinations
  • Neoplasm Proteins