Abstract
A one-pot multi-component reaction for the synthesis of beta-acetamido carbonyl compounds is reported. The reaction uses a variety of aldehydes, acetophenone derivatives or methyl acetoacetate, acetonitrile, and acetyl chloride in the presence of ferric perchlorate, a mild, efficient and inexpensive catalyst effective under solvent free conditions.
MeSH terms
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Acetamides / chemistry
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Acetonitriles / chemistry
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Acetophenones / chemistry
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Aldehydes / chemical synthesis*
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Aldehydes / chemistry
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Benzaldehydes / chemistry
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Esters / chemistry
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Ferric Compounds / chemistry*
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Ketones / chemical synthesis
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Ketones / chemistry*
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Perchlorates / chemistry*
Substances
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Acetamides
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Acetonitriles
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Acetophenones
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Aldehydes
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Benzaldehydes
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Esters
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Ferric Compounds
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Ketones
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Perchlorates
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iron perchlorate
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acetophenone
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benzaldehyde
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acetonitrile