Fe(ClO4)3 x 6H2O: a mild and efficient catalyst for one-pot three component synthesis of beta-acetamido carbonyl compounds under solvent-free conditions

Mol Divers. 2009 Aug;13(3):375-8. doi: 10.1007/s11030-009-9118-z. Epub 2009 Feb 25.

Abstract

A one-pot multi-component reaction for the synthesis of beta-acetamido carbonyl compounds is reported. The reaction uses a variety of aldehydes, acetophenone derivatives or methyl acetoacetate, acetonitrile, and acetyl chloride in the presence of ferric perchlorate, a mild, efficient and inexpensive catalyst effective under solvent free conditions.

MeSH terms

  • Acetamides / chemistry
  • Acetonitriles / chemistry
  • Acetophenones / chemistry
  • Aldehydes / chemical synthesis*
  • Aldehydes / chemistry
  • Benzaldehydes / chemistry
  • Esters / chemistry
  • Ferric Compounds / chemistry*
  • Ketones / chemical synthesis
  • Ketones / chemistry*
  • Perchlorates / chemistry*

Substances

  • Acetamides
  • Acetonitriles
  • Acetophenones
  • Aldehydes
  • Benzaldehydes
  • Esters
  • Ferric Compounds
  • Ketones
  • Perchlorates
  • iron perchlorate
  • acetophenone
  • benzaldehyde
  • acetonitrile