The authors suggest to distinguish the mesoaccumbocingulate dopaminergic system within the mesocorticolimbic dopaminergic system. It defines the formation of dependence on the influence of psychoactive drugs. The cortical center of the mesoaccumbocingulate dopaminergic system--anterior cingulate fields in rats (Cg1 and Cg3)--simultaneously represents the affective and motivation-mnestic center. The affective function of the rat anterior cingulate fields after the administration of psychoactive drugs, as well as the formation of dependence on them, is associated with the distribution of the dopaminergic endings of midbrain neurons in the nucleus accumbens and at the anterior cingulate fields, in particular, in the pregenual part.