Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo

Pigment Cell Melanoma Res. 2009 Jun;22(3):328-30. doi: 10.1111/j.1755-148X.2009.00560.x. Epub 2009 Feb 25.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Homeostasis*
  • Melanocytes / cytology
  • Melanocytes / metabolism*
  • Melanoma / metabolism*
  • Mice
  • Mice, Transgenic
  • Pigmentation*
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53