Computer controlled sequential simulation method: reconsidering evaluation of measurements from frequently sampled intravenous glucose tolerance test

Comput Methods Programs Biomed. 2009 Jul;95(1):1-9. doi: 10.1016/j.cmpb.2009.01.001. Epub 2009 Feb 26.

Abstract

This work describes quantification of regulatory mechanisms glucose-insulin, using data from a frequently sampled intravenous glucose tolerance test (FSIVGTT) and a mechanistically motivated model with time delays. FSIVGTT was performed on 14 young healthy volunteers. The constructed model computationally takes into account the form of the short-time glucose infusion used. Estimated model parameters are used to derive relationships quantifying the following mechanisms of regulatory systems glucose-insulin of the volunteers enrolled: (1) glucose uptake by body cells; (2) cessation (suppression) of glucose output from liver; (3) glucose clearance. The model presented correctly approximates initial peaks and subsequent waves in plasma glucose concentration-time profiles after the glucose infusion. These results indicate that the model presented is an appropriate tool for assessing glucose behavior during a FSIVGTT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose
  • Computational Biology / methods*
  • Data Interpretation, Statistical
  • Female
  • Glucose Tolerance Test / methods
  • Humans
  • Insulin / blood
  • Liver / metabolism
  • Male
  • Models, Statistical
  • Models, Theoretical
  • Reproducibility of Results
  • Signal Processing, Computer-Assisted*
  • Software

Substances

  • Blood Glucose
  • Insulin