Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones

Majid M Heravi; Bita Baghernejad; Hossein A Oskooie

doi:10.1007/s11030-009-9122-3

Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones

Mol Divers. 2009 Aug;13(3):385-7. doi: 10.1007/s11030-009-9122-3. Epub 2009 Feb 28.

Authors

Majid M Heravi¹, Bita Baghernejad, Hossein A Oskooie

Affiliation

¹ Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran. [email protected]

PMID: 19252994
DOI: 10.1007/s11030-009-9122-3

Abstract

Aldehydes, 1,3-indandione and cyclohexylisocyanide undergo smooth coupling-cyclization in water to produce the corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones in good yields. Water was used as a solvent to avoid the use of other highly toxic and environmentally unfavorable solvents for this synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry
Cyanides / chemistry
Cyclization
Cyclohexanes / chemistry
Furans / chemical synthesis*
Furans / chemistry
Green Chemistry Technology / methods*
Indans / chemistry
Temperature
Water / chemistry*

Substances

Aldehydes
Cyanides
Cyclohexanes
Furans
Indans
Water
1,3-indandione