Breast cancer quality control

Nat Cell Biol. 2009 Mar;11(3):239-41. doi: 10.1038/ncb0309-239.

Abstract

Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cell growth, suggesting a new role for quality-control mechanisms in suppressing cells with malignant potential.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • Cell Growth Processes
  • Female
  • Gene Expression Regulation, Neoplastic
  • Histone Acetyltransferases / metabolism
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Nuclear Receptor Coactivator 3
  • Trans-Activators / metabolism
  • Ubiquitin-Protein Ligases / metabolism*
  • Xenograft Model Antitumor Assays

Substances

  • Trans-Activators
  • Histone Acetyltransferases
  • NCOA3 protein, human
  • Ncoa3 protein, mouse
  • Nuclear Receptor Coactivator 3
  • STUB1 protein, human
  • Ubiquitin-Protein Ligases